STUDY OF REGIOSELECTIVITY IN CYANOMETHYLATION OF 4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1<i>Н</i>)-ONES

Authors

  • Виктор Н. Ткачук Институт органической химии НАН Украины
  • Сергей В. Мельников
  • Анастасия В. Воробей
  • Владимир А. Сукач
  • Михаил В. Вовк

DOI:

https://doi.org/10.1007/4790

Keywords:

cyanoacetic acid, 4-(trifluoromethyl)pyrimidinones, cyanomethylation, Mannich addition, Michael addition.

Abstract

Cyanoacetic acid reacted selectively with 4-(trifluoromethyl)pyrimidin-2(1Н)-ones with the formation of Michael addition–decarboxylation products in DMSO solution at 85°С and Mannich reaction products when the reagents were fused together under solvent-free conditions.

Author Biography

Виктор Н. Ткачук, Институт органической химии НАН Украины

отдел механизмов органических реакций

младший научный сотрудник

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Published

2019-02-13

Issue

Vol. 55 No. 1 (2019)

Section

Original Papers