

STUDY OF REGIOSELECTIVITY IN CYANOMETHYLATION OF 4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1Н)-ONES

Abstract
Cyanoacetic acid reacted selectively with 4-(trifluoromethyl)pyrimidin-2(1Н)-ones with the formation of Michael addition–decarboxylation products in DMSO solution at 85°С and Mannich reaction products when the reagents were fused together under solvent-free conditions.
Keywords
cyanoacetic acid, 4-(trifluoromethyl)pyrimidinones, cyanomethylation, Mannich addition, Michael addition.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv