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STUDY OF REGIOSELECTIVITY IN CYANOMETHYLATION OF 4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1Н)-ONES

Виктор Н. Ткачук, Сергей В. Мельников, Анастасия В. Воробей, Владимир А. Сукач, Михаил В. Вовк
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Abstract


Cyanoacetic acid reacted selectively with 4-(trifluoromethyl)pyrimidin-2(1Н)-ones with the formation of Michael addition–decarboxylation products in DMSO solution at 85°С and Mannich reaction products when the reagents were fused together under solvent-free conditions.

Keywords


cyanoacetic acid, 4-(trifluoromethyl)pyrimidinones, cyanomethylation, Mannich addition, Michael addition.

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