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SYNTHESIS AND PROPERTIES OF 1-[(ADAMANTAN-1-YL)METHYL]- 3-PYRAZOLYL UREAS

Владимир С. Дьяченко, Дмитрий В. Данилов, Татьяна К. Шкинева, Ирина А. Вацадзе, Владимир В. Бурмистров, Геннадий Михайлович Бутов
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Abstract


A series of 1,3-disubstituted ureas containing 1,3,5-trisubstituted pyrazole and (adamantan-1-yl)methyl fragments were synthesized in the reaction of 1-(isocyanatomethyl)adamantane with 3- or 4-aminopyrazoles under mild conditions in 67–92% yields. The inhibitory activity of the obtained compounds with respect to human soluble epoxide hydrolase (sEH) was 16.2–50.2 nmol/l, with solubility in water of 45–85 μmol/l.

Keywords


adamantane derivatives, amines, 1,3-disubstituted ureas, isocyanates, pyrazoles, soluble epoxide hydrolase (sEH), inhibitors.

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