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CHEMOSELECTIVE AMINOMETHYLATION OF HARMOL

Светлана Петровна Бондаренко, Вера Николаевна Ищенко, Михаил Сергеевич Фрасинюк
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Abstract


Aminomethylation of harmol (7-hydroxy-1-methyl-β-carboline) was investigated. It was shown that the reaction proceeds chemoselectively to form 8-aminomethyl derivatives by the action of aminals or a mixture of a secondary amine with paraform. When primary amines and an excess of paraform were used in the Mannich reaction, 2,3-dihydro-1H-pyrido[4',3':4,5]pyrrolo[3,2,1-ij]quinazolin-4-ol and 1,2,3,11-tetrahydro[1,3]oxazino[6,5-g]pyrido[3,4-b]indole derivatives are formed.

Authors: Svitlana P. Bondarenko, Vera N. Ishchenko, Mykhaylo S. Frasinyuk

 


Keywords


β-carboline; harmol; Mannich bases; 1H-pyrido[4',3':4,5]pyrrolo[3,2,1-ij]quinazoline; aminomethylation

Full Text: PDF (Russian) Supplementary File(s): Suppl Info (1MB)


 

 

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