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SYNTHESIS OF HYBRID MOLECULES CONTAINING PYRIMIDINE AND DITERPENE ALKALOID LAPPACONITINE FRAGMENTS

Эльвира Э. Шульц, Кирилл П. Черемных, Виктор А. Савельев, Олег П. Шкурко
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Abstract


The cross coupling of 5'-ethynyllappaconitine with benzoic acid chlorides under the conditions of the Sonogashira reaction in benzene leads to the corresponding 5-alkynones. By condensation of the obtained 5'-alkynones with amidines, compounds with hybrid structure containing fragments of a diterpene alkaloid and pyrimidine were synthesized. The yields of the target compounds were 67–90%. The possibility of carrying out the cross coupling – condensation reaction as a one-pot synthesis is demonstrated.

Keywords


alkaloids, alkynes, amidines, pyrimidines, cross coupling, one-pot synthesis.

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