

SYNTHESIS OF HYBRID MOLECULES CONTAINING PYRIMIDINE AND DITERPENE ALKALOID LAPPACONITINE FRAGMENTS

Abstract
The cross coupling of 5'-ethynyllappaconitine with benzoic acid chlorides under the conditions of the Sonogashira reaction in benzene leads to the corresponding 5-alkynones. By condensation of the obtained 5'-alkynones with amidines, compounds with hybrid structure containing fragments of a diterpene alkaloid and pyrimidine were synthesized. The yields of the target compounds were 67–90%. The possibility of carrying out the cross coupling – condensation reaction as a one-pot synthesis is demonstrated.
Keywords
alkaloids, alkynes, amidines, pyrimidines, cross coupling, one-pot synthesis.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv