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SYNTHESIS OF SUBSTITUTED IMIDAZO[1,2-a]PYRIDIN-3-YL-ACETIC ACIDS BY MULTICOMPONENT CONDENSATION OF 2-AMINOPYRIDINES WITH ARYLGLYOXALS AND MELDRUM'S ACID
Abstract
A simple and effective method for the synthesis of substituted imidazo[1,2-a]pyridin-3-yl-acetic acids has been developed based on the multicomponent condensation of 2-aminopyridines with arylglyoxals and Meldrum's acid.
Keywords
2-aminopyridines, arylglyoxals, imidazo[1,2-a]pyridines, imidazo[1,2-a]pyridin-3-yl-acetic acids, Meldrum's acid, multicomponent reaction.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv