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AN EFFICIENT METHOD FOR THE SYNTHESIS OF 2-THIAZOLEACETIC ACID N-SULFONYL AMIDINES
Abstract
A three-step method was designed and developed on the basis of retrosynthetic analysis for the synthesis of hybrid molecules containing
a thiazole ring and an N-sulfonyl amidine fragment, connected by a methylene linker. The mechanism of the last step involves the formation of intermediate 1,2,3,4-thiatriazoles and their transformation into the final products as a result of the elimination of molecular nitrogen and sulfur.
a thiazole ring and an N-sulfonyl amidine fragment, connected by a methylene linker. The mechanism of the last step involves the formation of intermediate 1,2,3,4-thiatriazoles and their transformation into the final products as a result of the elimination of molecular nitrogen and sulfur.
Keywords
azides, thiazoles, 1,2,3,4-thiatriazoles, thioamides, cycloaddition.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv