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AN EFFICIENT METHOD FOR THE SYNTHESIS OF 2-THIAZOLEACETIC ACID N-SULFONYL AMIDINES

Владимир Г. Илькин, Василий А. Бакулев, Вера С. Берсенева, Павел А. Слепухин
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Abstract


A three-step method was designed and developed on the basis of retrosynthetic analysis for the synthesis of hybrid molecules containing
a thiazole ring and an N-sulfonyl amidine fragment, connected by a methylene linker. The mechanism of the last step involves the formation of intermediate 1,2,3,4-thiatriazoles and their transformation into the final products as a result of the elimination of molecular nitrogen and sulfur.

Keywords


azides, thiazoles, 1,2,3,4-thiatriazoles, thioamides, cycloaddition.

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv