Open Access Open Access  Restricted Access Subscription Access

ANNULATION OF PYRROLE RING IN 4-ACYLPYRIDINE-3,5-DICARBONITRILES IN THE PRESENCE OF AMMONIA

Артур А. Григорьев, Яков С. Каюков, Анастасия Л. Никифорова, Сергей В. Карпов, Екатерина С. Щегравина, Ольга В. Каюкова, Виктор А. Тафеенко
Cover Image

Abstract


4-Acyl-2-amino-6-chloropyridine-3,5-dicarbonitriles underwent heterocyclization in the presence of ammonia in aqueous dioxane medium, involving the ortho-ketonitrile fragment while preserving the halogen atom. The pyrrole ring annulation process proceeded regioselectively with the formation of a single positional isomer.

Keywords


pyridine-3,5-dicarbonitriles, heteroannulation, rearrangement, regioselectivity.

Full Text: PDF (Russian) Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv