

ANNULATION OF PYRROLE RING IN 4-ACYLPYRIDINE-3,5-DICARBONITRILES IN THE PRESENCE OF AMMONIA

Abstract
4-Acyl-2-amino-6-chloropyridine-3,5-dicarbonitriles underwent heterocyclization in the presence of ammonia in aqueous dioxane medium, involving the ortho-ketonitrile fragment while preserving the halogen atom. The pyrrole ring annulation process proceeded regioselectively with the formation of a single positional isomer.
Keywords
pyridine-3,5-dicarbonitriles, heteroannulation, rearrangement, regioselectivity.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv