THE DIRECTION OF RING FISSION OF UNSYMMETRICALLY SUBSTITUTED SUCCINIC ANHYDRIDES. 1. INTERACTION OF α-TETRAHYDROFURYLSUCCINIC ANHYDRIDE WITH BENZYLAMINE AND 2,5-XYLIDINE

Г. Г. Галустьян, М. Г. Левкович, Н. Д. Абдуллаев

Abstract


The reaction of α-tetrahydrofurylsuccinic anhydride with amines proceeds regiospecifically at room temperature with the formation of N-substituted 2-(α-tetrahydrofuryl)succinamic acids. On increasing the temperature the reaction direction is changed and the 3 isomer is mainly formed.

Authors: G. G. Galust'yan; M. G. Levkovich; and N. D. Abdullaev.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (12), pp 1402-1408

http://link.springer.com/article/10.1023/A%3A1017514228053


Keywords


amic acids; anilines; unsymmetrically substituted succinic anhydrides; double resonance; direction of nucleophilic attack; Overhauser effect

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