A NOVEL ONE-POT SYNTHESIS METHOD OF 3,4,5-TRIARYL-SUBSTITUTED 1,2,4-TRIAZOLES
Authors
Игорь К. Якущенко
Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 1 Akademika Semenova Ave., Chernogolovka 142432, Moscow region, Russia
Наталья Н. Поздеева
Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 1 Akademika Semenova Ave., Chernogolovka 142432, Moscow region, Russia
Святослав Я. Гадомский
Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 1 Akademika Semenova Ave., Chernogolovka 142432, Moscow region, Russia
A novel method for the preparation of 3,4,5-triaryl-substituted 1,2,4-triazoles by the reaction of hydrazides with secondary amides in polyphosphoric ester has been developed. The new method is characterized by mild conditions and ease of synthesis, including the stages of isolation and purification of the product. Additionally, product structures were confirmed by counter synthesis. It was shown that the proposed method is suitable for producing 1,2,4-triazoles with phenolic substituents without the stages of the protection and deprotection of the hydroxyl group. Using the new method, five 3,4,5-substituted 1,2,4-triazoles were obtained for the first time.
Author Biographies
Игорь К. Якущенко, Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 1 Akademika Semenova Ave., Chernogolovka 142432, Moscow region, Russia
старший научный сотрудник, кандидат химических наук
Наталья Н. Поздеева, Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 1 Akademika Semenova Ave., Chernogolovka 142432, Moscow region, Russia
инженер
Святослав Я. Гадомский, Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 1 Akademika Semenova Ave., Chernogolovka 142432, Moscow region, Russia
