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DIRECT SYNTHESIS OF N-SUBSTITUTED 1,3-OXAZOLIDINES VIA A HETERO-DOMINO PETASIS BORONO-MANNICH REACTION OF 1,2-AMINO ALCOHOLS, FORMALDEHYDE, AND ORGANOBORONIC ACIDS

Yiting Zheng, Lu Sun, Jiayi Wang, Gonghua Song
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Abstract


A simple and convenient approach to the synthesis of N-substituted 1,3-oxazolidines via a hetero-domino Petasis borono-Mannich reaction of 1,2-amino alcohols, formaldehyde, and organoboronic acids has been reported. The transformation provides an effective and complementary pathway toward 1,3-oxazolidine derivatives.

Keywords


1,3-oxazolidines; cyclization; hetero-domino reaction; Petasis borono-Mannich reaction; three-component reaction

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