

SYNTHESIS OF N-SUBSTITUTED 2-AMINOMETHYL-5-METHYL-7-PHENYLOXAZOLO[5,4-b]PYRIDINES

Abstract
2-(Chloromethyl)-5-methyl-7-phenyloxazolo[5,4-b]pyridine was obtained by intramolecular cyclization based on the previously synthesized 2-chloro-N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)acetamide. The possibility of its use in the synthesis of previously unknown 2-aminomethyloxazolo[5,4-b]pyridine derivatives by nucleophilic substitution with various amines and a cyclic amide has been shown.
Keywords
2-aminomethyloxazolo[5,4-b]pyridine derivatives; 3-amino-4-phenylpyridin-2(1Н)-one; chloroacetamide; oxazolo[5,4-b]-pyridine; intramolecular cyclization; nucleophilic substitution.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv