STUDIES IN THE IMIDAZOLE SERIES. 100. SYNTHESIS OF DERIVATIVES OF IMIDAZO[1,2-a]PYRIMIDINE FROM 2-AMINOPYRIMIDINES, METHYL ARYL KETONES, AND HALOGENS

П. М. Кочергин, И. А. Мазур, Г. К. Рогульченко, Е. В. Александрова, Б. Е. Мандриченко

Abstract


We have synthesized imidazo[1,2-a]pyrimidine derivatives by reaction of 2-aminopyrimidines with methyl aryl ketones and halogens (bromine, iodine). Using bromine leads to formation of 6-bromo- and 3,6 dibromo-substituted 2-arylimidazo[1,2-a]pyrimidines.

Authors: P. M. Kochergin, I. A. Mazur, G. K. Rogul'chenko, E. V. Aleksandrova, and B. E. Mandrichenko.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (12), pp 1437-1440

http://link.springer.com/article/10.1023/A%3A1017574413941


Keywords


imidazopyrimidines; aminopyrimidines; halogens; imidazole; methyl aryl ketones; cyclization

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