NUCLEOPHILIC SUBSTITUTION IN 1,5-BENZODIAZEPIN-2-ONES

В. И. Божанов, С. П. Ивонин

Abstract


The reaction of 3-bromo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one with cyclic amines gives 3 aminoalkyl-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one. Thiazolo[4,5-b][1,5]benzodiazepine was isolated along with the substitution product when thiourea was used.

Authors: V. I. Bozhanov and S. P. Ivonin.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (12), pp 1446-1448

http://link.springer.com/article/10.1023/A%3A1017578614850


Keywords


1,5-benzodiazepin-2-ones; thiazolo[4,5-b][1,5]benzodiazepine; bromination; phase-transfer catalysis; nucleophilic substitution

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