SYNTHESIS OF 7-ARYLIMIDAZO[1,2- a ]PYRAZIN-8(7 H )-ONE DERIVATIVES

Svitlana S. Kovalenko; Oleksandr G. Drushlyak; Sergiy M. Kovalenko; Natalya D. Bunyatyan; Dmitry V. Kravchenko; Alexandre V. Ivachtchenko

doi:10.1007/4941

SYNTHESIS OF 7-ARYLIMIDAZO[1,2-a]PYRAZIN-8(7H)-ONE DERIVATIVES

Svitlana S. Kovalenko, Oleksandr G. Drushlyak, Sergiy M. Kovalenko, Natalya D. Bunyatyan, Dmitry V. Kravchenko, Alexandre V. Ivachtchenko

Abstract

A suitable approach to the synthesis of 7-arylimidazo[1,2-a]pyrazin-8(7H)-ones starting from esters of oxalic acid monoamides via cyclization of intermediate 3-aminopyrazin-2-ones with α-halocarbonyl compounds has been suggested.

Keywords

3-aminopyrazin-2(1H)-one; 2-halophenylethanone; imidazo[1,2-a]pyrazin-8(7H)-one; 3-methoxypyrazin-2(1H)-one; pyrazine-2,3-dione; cyclization

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Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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