SYNTHESIS OF 7-ARYLIMIDAZO[1,2-<i>a</i>]PYRAZIN-8(7<i>H</i>)-ONE DERIVATIVES

Authors

  • Svitlana S. Kovalenko National University of Pharmacy, 53 Pushkinska St., Kharkiv 61002
  • Oleksandr G. Drushlyak National University of Pharmacy, 53 Pushkinska St., Kharkiv 61002
  • Sergiy M. Kovalenko V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61077
  • Natalya D. Bunyatyan I. M. Sechenov First Moscow State Medical University (Sechenovskiy University), 8 Trubeckaya St., Moscow, 119991. Scientific Centre for Expert Evaluation of Medicinal Products, 8 Build. 2 Petrovsky Blvd., Moscow 127051
  • Dmitry V. Kravchenko Chemical Diversity Research Institute, 2a-1 Rabochaya St., Khimki, Moscow Region 141400
  • Alexandre V. Ivachtchenko ChemDiv, Inc., 6605 Nancy Ridge Drive, San Diego, CA 92121

DOI:

https://doi.org/10.1007/4941

Keywords:

3-aminopyrazin-2(1H)-one, 2-halophenylethanone, imidazo[1, 2-a]pyrazin-8(7H)-one, 3-methoxypyrazin-2(1H)-one, pyrazine-2, 3-dione, cyclization

Abstract

A suitable approach to the synthesis of 7-arylimidazo[1,2-a]pyrazin-8(7H)-ones starting from esters of oxalic acid monoamides via cyclization of intermediate 3-aminopyrazin-2-ones with α-halocarbonyl compounds has been suggested.

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Published

2019-05-22

Issue

Vol. 55 No. 4/5 (2019): In memory of Professor Valerii Dmitrievich Orlov

Section

Original Papers