MULTICOMPONENT SYNTHESIS AND MOLECULAR STRUCTURE OF 3-AMINO-2-AROYL(ALKOXYCARBONYL, ARYLCARBAMOYL)-4-ARYL(HETARYL)- 5-ARYLCARBAMOYL-6-METHYLTHIENO[2,3-b]PYRIDINES

Abstract

A new, effective method has been developed for the synthesis of functionalized thieno[2,3-b]pyridines by multicomponent condensation reactions of aromatic and heteroaromatic aldehydes, cyanothioacetamide, acetoacetanilides, and alkylating agents containing activated methylene groups. The structures of 3-amino-2-benzoyl-4-(furan-2-yl)-6-methyl-N-phenylthieno[2,3-b]pyridine-5-carboxamide, 3-amino-N²-(4-bromophenyl)-N⁵-(4-chlorophenyl)-6-methyl-4-(3-methylthiophen-2-yl)thieno[2,3-b]pyridine-2,5-dicarboxamide, and 3-amino-4-(2-chlorophenyl)-N-(4-chlorophenyl)-6-methyl-2-(4-methylbenzoyl)thieno[2,3-b]pyridine-5-carboxamide were studied by X-ray structural analysis.