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CONJUGATED 2,4,1- AND 1,4,3-ENYNONES AS POLYCENTRIC ELECTROPHILES IN SYNTHESIS OF HETEROCYCLIC COMPOUNDS

Александр А. Голованов, Дмитрий М. Гусев, Иван С. Один, Семен C. Злотский
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Abstract


This review article provides critical analysis of literature data regarding the heterocyclization reactions of compounds containing alk-2-en-4-yn-1-one and alk-1-en-4-yn-3-one moieties. We discuss the reactions leading to the formation of furans, 2,3-dihydropyrans, 1,2,3-triazoles, 4,5-dihydro-1Н-pyrazoles, pyrazoles, isoxazoles, pyrimidines, aziridines, as well as a range of more complex fused ring systems. The biological activity and photophysical properties of the obtained heterocyclic compounds are described. The attention is mainly focused on the studies published during the last 5 years. A total of 87 references are given.

Authors: Alexander A. Golovanov*, Dmitry M. Gusev,
Ivan S. Odin, Simon S. Zlotskii


Keywords


aziridines; conjugated enynones; furans; pyrazoles; pyrimidines; 1,2,3-triazoles; biological activity; cyclization; 1,3-dipolar cycloaddition; nucleophilic addition

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