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SYNTHESIS AND BIOACTIVITY OF NOVEL (γ-PIPERIDONO)DIBENZO-33-AZA-14-CROWN-3 ETHERS

Thi Nhung Dao, Hong Hieu Truong, Van Boi Luu, Anatoly T. Soldatenkov, Nadezhda M. Kolyadina, Alena N. Kulakova, Victor N. Khrustalev, Ayalev T. Wodajo, Hong Quan Nguyen, Thi Tan Van Tran, Tuan Anh Le
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Abstract


Three-component reaction of polyether-linked bisnaphthaldehyde, ketone derivative, and ammonium acetate afforded seven new azacrown ethers containing γ-piperidone fragment with moderate yields. Most of the compounds were tested for their bioactivity. (3,5-Diethylpiperidono)azacrown ether showed significant cytotoxicity against Hep-G2, Lu1, RD, and MCF-7 cell lines. In addition, three of the synthesized azacrown ethers showed positive effect in antimicrobial test against Aspergillus niger.


Keywords


azacrown ether; 2,2'-[oxybis(ethane-2,1-diyloxy)]dinaphthalene-1-carbaldehyde; Petrenko–Kritschenko reaction; cytotoxicity; X-ray diffraction study

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