

SYNTHESIS AND BIOACTIVITY OF NOVEL (γ-PIPERIDONO)DIBENZO-33-AZA-14-CROWN-3 ETHERS

Abstract
Three-component reaction of polyether-linked bisnaphthaldehyde, ketone derivative, and ammonium acetate afforded seven new azacrown ethers containing γ-piperidone fragment with moderate yields. Most of the compounds were tested for their bioactivity. (3,5-Diethylpiperidono)azacrown ether showed significant cytotoxicity against Hep-G2, Lu1, RD, and MCF-7 cell lines. In addition, three of the synthesized azacrown ethers showed positive effect in antimicrobial test against Aspergillus niger.
Keywords
azacrown ether; 2,2'-[oxybis(ethane-2,1-diyloxy)]dinaphthalene-1-carbaldehyde; Petrenko–Kritschenko reaction; cytotoxicity; X-ray diffraction study
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv