SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL POLYCYCLIC THIENOPYRIDAZINE DERIVATIVES

Authors

  • Ahmed A. Fayed Department of Respiratory Therapy, Faculty of Medical Rehabilitation Sciences, Taibah University, Madinah Munawara 22624, Saudi Arabia;
  • Mahmoud N. M. Yousif National Research Center, Dokki 12622, Cairo, Egypt
  • Taha T. Abdelgawad Department of Chest Medicine, Faculty of Medicine, Mansoura University,Mansoura 35516, Egypt;
  • Abd El-Galil E. Amr College of Pharmacy, king saud unisversity
  • Nabil M. Yousif National Research Center, Dokki 12622, Cairo, Egypt
  • Farouk A. Gad National Research Center, Dokki 12622, Cairo, Egypt

DOI:

https://doi.org/10.1007/5002

Keywords:

pyridothienocinnoline, pyrimidothienocinnoline, thiazinothienocinnoline, thiazolopyrimidothienocinnoline, thienocinnoline, thienopyridazine, triazolopyrimidothienocinnoline, antimicrobial agent.

Abstract

A series of novel thienopyridazine derivatives has been synthesized using 9-aminodibenzo[f,h]thieno[2,3-c]cinnoline-8-carbonitrile as starting material. The target products exhibit promising antibacterial and antifungal properties against bacterial strains E. coli, S. aureus, B. subtilis, and K. pneumoniae and fungal strains A. fumigatus and C. albicans. The highest antimicrobial activity against all tested
microorganisms demonstrate pyridothienocinnoline derivatives.

Author Biography

Abd El-Galil E. Amr, College of Pharmacy, king saud unisversity

Pharmaceutical Chemistry

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Published

2019-08-14

Issue

Vol. 55 No. 8 (2019)

Section

Original Papers