PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES IN THE SYNTHESIS OF A NOVEL HETEROCYCLIC SYSTEM 2a,5a,7-TRIAZAACENAPHTHYLENE

Abstract

A convenient method for the synthesis of methyl 8-oxo-3H,8H-2a,5a,7-triazaacenaphthylene-2-carboxylate by iodination of 7-allyl-4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid methyl ester followed by elimination of hydrogen iodide has been developed. The use of 4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid as the starting compound led to the formation of iodomethylpyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazine, a promising precursor for the synthesis of a new tricyclic system based on pyrrolo[2,3-d]pyrimidine.

Authors: Lyubov V. Muzychka, Iryna O. Yaremchuk, Evgenii V. Verves, Oleg B. Smolii*