8-(METHYL(PHENYL)SULFONYL)-2,6-DIHYDROIMIDAZO[1,2- c ]-PYRIMIDIN-5(3 Н )-ONES AND 9-(METHYL(PHENYL)SULFONYL)-2,3,4,7-DIHYDRO-6 H -PYRIMIDO[1,6- a ]PYRIMIDIN-6-ONES: SYNTHESIS AND ANTIVIRAL ACTIVITY

Роман Н. Соломянный; Ольга В. Шаблыкина; Виктория С. Москвина; Владимир П. Хиля; Эдуард Б. Русанов; Владимир С. Броварец

doi:10.1007/5015

8-(METHYL(PHENYL)SULFONYL)-2,6-DIHYDROIMIDAZO[1,2-c]-PYRIMIDIN-5(3Н)-ONES AND 9-(METHYL(PHENYL)SULFONYL)-2,3,4,7-DIHYDRO-6H-PYRIMIDO[1,6-a]PYRIMIDIN-6-ONES: SYNTHESIS AND ANTIVIRAL ACTIVITY

Роман Н. Соломянный, Ольга В. Шаблыкина, Виктория С. Москвина, Владимир П. Хиля, Эдуард Б. Русанов, Владимир С. Броварец

Abstract

A convenient method for the synthesis of novel sulfonic cytosine derivatives, 8-(methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2-c]-pyrimidin-5(3Н)-ones and 9-(methyl(phenyl)sulfonyl)-2,3,4,7-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-ones, has been developed based on the reaction of 3-amino-2-(methyl(phenyl)sulfonyl)acrylonitriles with 2-chloroethyl isocyanate and 3-chloropropyl isocyanate. The resulting heteryl sulfones possess antiviral activity.

Keywords

3-amino-2-(methyl(phenyl)sulfonyl)acrylonitriles, 8-(methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2-c]pyrimidin-5(3Н)-ones, 9-(methyl(phenyl)sulfonyl)-2,3,4,7-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-ones, heterocyclization, antiviral activity.

Full Text: PDF (Russian) Open Access

Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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