

AN EXPEDITIOUS ULTRASOUND-INITIATED GREEN SYNTHESIS OF 1,2,4-THIADIAZOLES IN WATER

Abstract
A convenient, environmentally benign, metal- and catalyst-free protocol has been developed for the conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives with chloranil under ultrasound irradiation in water at room temperature. This paper describes a general procedure for the synthesis of different 1,2,4-thiadiazoles in excellent yield in short reaction time via sonochemistry.
Keywords
aqueous medium; heterocycles; metal- and catalyst-free; one-pot synthesis; oxidative coupling; ultrasound irradiation.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv