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AN EXPEDITIOUS ULTRASOUND-INITIATED GREEN SYNTHESIS OF 1,2,4-THIADIAZOLES IN WATER

Swati Chauhan, Pratibha Verma, Ankush Mishra, Vandana Srivastava
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Abstract


A convenient, environmentally benign, metal- and catalyst-free protocol has been developed for the conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives with chloranil under ultrasound irradiation in water at room temperature. This paper describes a general procedure for the synthesis of different 1,2,4-thiadiazoles in excellent yield in short reaction time via sonochemistry.


Keywords


aqueous medium; heterocycles; metal- and catalyst-free; one-pot synthesis; oxidative coupling; ultrasound irradiation.

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