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SYNTHESIS OF FERROCENE-BASED POLYSUBSTITUTED PYRROLIDINES

Wensheng Zhang, Wensheng Xu, Chunyu Ma, Yan Li
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Abstract


Ferrocene-based polysubstituted pyrrolidines can be synthesized efficiently via 1,3-dipolar cycloaddition of azomethine ylides generated from α-amino acid ester and ferrocenecarboxaldehyde with N-substituted maleimide at 125°C in MeCN. The structures of the products were confirmed by 1H, 13C NMR, and HRMS data.


Keywords


azomethine ylides; ferrocene; pyrrolidine; 1,3-dipolar cycloaddition.

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