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ONE-POT DIASTEREOSELECTIVE SYNTHESIS OF FUNCTIONALIZED 4,5-DIHYDROPYRROLES BY REACTIONS OF ARYLGLYOXALS, β-DICARBONYL COMPOUNDS, AND AROMATIC AMINES

Надежда Н. Колос, Сергей А. Карпань, Ирина В. Омельченко, Наталья В. Чечина, Федор Г. Яременко
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Abstract


A multicomponent reaction of arylglyoxal hydrates, acetylacetone or acetoacetic ester, aniline or its 3(4)-substituted analogs in 1:1:2 ratio occurred upon stirring in methanol, giving 4-arylamino-5-hydroxypyrroline derivatives containing 4,5-dihydroxypyrrolines as impurities.

Keywords


acetylacetone; acetoacetic ester; arylglyoxal hydrates; 4,5-dihydropyrroles; domino reactions.

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