THREE-COMPONENT CONDENSATION OF 4-IMINO-1-PHENYLIMIDAZOLIDIN-2-ONE WITH ALDEHYDES AND MELDRUM'S ACID: SYNTHESIS OF IMIDAZO[4,5- b ]PYRIDINE-2,5(4 H ,6 H )-DIONES AND 5-SUBSTITUTED 1-PHENYLHYDANTOINS

Константин С. Крылов; Андрей Н. Комогорцев; Борис В. Личицкий; Артем Н. Фахрутдинов; Аркадий А. Дудинов; Михаил М. Краюшкин

doi:10.1007/5071

THREE-COMPONENT CONDENSATION OF 4-IMINO-1-PHENYLIMIDAZOLIDIN-2-ONE WITH ALDEHYDES AND MELDRUM'S ACID: SYNTHESIS OF IMIDAZO[4,5-b]PYRIDINE-2,5(4H,6H)-DIONES AND 5-SUBSTITUTED 1-PHENYLHYDANTOINS

Константин С. Крылов, Андрей Н. Комогорцев, Борис В. Личицкий, Артем Н. Фахрутдинов, Аркадий А. Дудинов, Михаил М. Краюшкин

Abstract

A convenient method for the synthesis of previously unknown imidazo[4,5-b]pyridine-2,5(4H,6H)-diones has been developed, based on a three-component condensation of 4-imino-1-phenylimidazolidin-2-one with aldehydes and Meldrum's acid. The possibility of accessing 5-substituted 1-phenylhydantoins based on the acid hydrolysis of imidazo[4,5-b]pyridine-2,5(4H,6H)-diones was shown.

Keywords

aldehydes; imidazo[4,5-b]pyridine-2,5(4H,6H)-diones; 4-imino-1-phenylimidazolidin-2-one; Meldrum's acid; 5-substituted 1-phenylhydantoins; three-component condensation.

Full Text: PDF (Russian) Open Access

Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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