Open Access Open Access  Restricted Access Subscription Access

SYNTHESIS AND CHARACTERIZATION OF NEW PYRIDO- AND PYRAZOLOPYRIMIDINE DERIVATIVES USING 2-SUBSTITUTED VINAMIDINIUM SALTS

Abdolmohammad Mehranpour, Sedigheh Hashemnia, Mona Bornak
Cover Image

Abstract


Several novel pyrido- and pyrazolopyrimidine derivatives were readily synthesized by reaction of 6-aminouracil or 3(5)-aminopyrazole with 2-substituted vinamidinium salts. The reactions were carried out in a relatively short time without any base or catalyst. The structures of the synthesized compounds were confirmed by UV-vis, IR, and 1H and 13C NMR spectroscopy, as well as mass spectrometry and elemental analysis. The obtained results showed that tautomers of 3(5)-amino-1(H)-pyrazole can participate in the formation of the new pyrido- and pyrazolopyrimidine derivatives with their respective most nucleophilic centers N-2 and C-4.


Keywords


pyrazolo[3,4-b]pyridine; pyrazolo[1,5-a]pyrimidine; pyrido[2,3-d]pyrimidine; vinamidinium salts

Full Text: PDF Supplementary File(s): Supporting information (2MB)


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv