

FLUORINATED 1,3-BENZOTHIAZIN-4-ONES CONTAINING FLUOROQUINOLONE FRAGMENT

Abstract
We have developed an efficient synthetic approach to potential antibacterial agents with double mechanism of action through the combination of antibacterial fluoroquinolones with 1,3-benzothiazin-4-ones.
Keywords
fluorobenzothiazin-4-ones; o-fluorobenzoyl isothiocyanates; 7-hydrazinoquinolone-3-carboxylic acid; quinolone-3-carboxylic acid hydrazides; cyclocondensation
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv