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THE FIRST EXAMPLE OF PALLADIUM(II)-CATALYZED OXIDATIVE C–N CROSS COUPLING OF 2H-IMIDAZOLE 1-OXIDE WITH AZOLES

Алексей А. Акулов, Михаил В. Вараксин, Валерий Н. Чарушин, Олег Н. Чупахин
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Abstract


We report the first direct nucleophilic C–H-functionalization of cyclic aldonitrone, a derivative of 2H-imidazole 1-oxide, with 1H-imidazole and 3,5-dimethylpyrazole rings using oxidative C–N cross-coupling reactions in the presence of palladium(II) catalysts. The obtained new bisheterocyclic N-oxides may attract interest as molecules with potential biological activity and as functional organic materials.

 


Keywords


imidazoles; nitrones; N-oxides; palladium; pyrazoles; C–H functionalization; dehydrogenative cross coupling

Full Text: PDF (Russian) Supplementary File(s): Supporting info (3MB)


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv