HETEROCYCLIZATION OF ALICYCLIC 1,5-DIKETONES. SYNTHESIS OF N-SUBSTITUTED 5-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YL)PENTANOIC ACIDS ON THE BASIS OF (2,2'-METHANEDIYL)BISCYCLOHEXANONE AND PRIMARY AMINES

Abstract

The bisulfite adduct, formed upon treatment of (2,2'-methanediyl)biscyclohexanone with aqueos sodium bisulfite solution in the presence of acetic acid, subsequently reacted under the same conditions with certain aromatic and aliphatic primary amines, giving moderate yields of N-substituted 5-(4,5,6,7-tetrahydro-1H-indol-2-yl)pentanoic acids.