SYNTHESIS OF FUSED SYSTEMS CONTAINING AN ANGULAR NITROGEN ATOM FROM SUBSTITUTED 2 BENZYL 4 HYDRAZINOPYRIDIMINES

Abstract

The condensation of substituted 2‑benzyl‑4‑hydrazinopyrimidines with phenylpyruvic acid gave the corresponding hydrazones, which cyclize upon the action of POCl₃ to give derivatives of pyrimido[6,1‑c][1,2,4]‑triazine. The substituted 2‑benzylpyrimidinylhydrazides of some carboxylic acids react with POCl₃ to give 1,2,4‑triazolo[4,3‑c]pyrimidines. The reaction of 7‑benzyl‑5‑methyl‑1‑phenyl‑1,2,4‑triazolo[2,3‑c]pyrimidine with sodium ethylate leads to rearrangement and formation of 7‑benzyl‑5‑methyl‑2‑phenyl‑1,2,4‑triazolo[2,3‑c]pyrimidine.

Authors: G. G. Danagulyan, L. G. Sahakyan, and G. A. Panosyan.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (2), pp 185-189

http://link.springer.com/article/10.1007/BF02283550