ONE-STEP SYNTHESIS OF 1,4-BIS(HET)ARYLISOQUINOLINES BY THE REACTION OF 1,2,4-TRIAZINES WITH ARYNES

Дмитрий С. Копчук; Игорь Л. Никонов; Альберт Ф. Хасанов; Сравия Гундала; Алексей П. Криночкин; Павел А. Слепухин; Григорий В. Зырянов; Падмавати Венкатапурам; Олег Н. Чупахин; Валерий Н. Чарушин

doi:10.1007/5114

ONE-STEP SYNTHESIS OF 1,4-BIS(HET)ARYLISOQUINOLINES BY THE REACTION OF 1,2,4-TRIAZINES WITH ARYNES

Дмитрий С. Копчук, Игорь Л. Никонов, Альберт Ф. Хасанов, Сравия Гундала, Алексей П. Криночкин, Павел А. Слепухин, Григорий В. Зырянов, Падмавати Венкатапурам, Олег Н. Чупахин, Валерий Н. Чарушин

Abstract

The reaction of 3,6-bis(het)aryl-1,2,4-triazines (hetaryl ≠ 2-pyridyl) with aryne intermediates generated in situ was studied. As a result, novel 1,4-bis(het)arylisoquinolines were synthesized with yields of up to 45%. The main rules of the reactions were studied, and the obtained experimental data were compared with those described in the literature.

Keywords

anthranilic acids; aryne intermediates; 1,2,4-triazines; aza-Diels–Alder reaction.

Full Text: PDF (Russian) Open Access

Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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