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EFFECTIVE METHOD FOR THE SYNTHESIS OF AZOLO[1,5-a]PYRIMIDIN-7-AMINES

Денис А. Газизов, Виктор В. Федотов, Евгений Б. Горбунов, Евгений Н. Уломский, Олег С. Ельцов, Геннадий Л. Русинов, Владимир Л. Русинов
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Abstract


Condensation of aminoazoles with (2E)-(3-morpholin-4-yl)acrylonitrile and 3,3-diethoxypropionitrile was used to synthesize a series of azolo[1,5-a]pyrimidin-7-amines. It was established that the reactions with certain aminotriazoles gave mixtures of regioisomers: azolo[1,5-а]pyrimidin-7-amines and azolo[4,3-а]pyrimidin-5-amines.

Keywords


azolo[1,5-a]pyrimidin-7-amines; 3,3-diethoxypropionitrile; (2E)-(3-morpholin-4-yl)acrylonitrile; Dimroth rearrangement; heterocyclization

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