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SYNTHESIS OF 2-(PYRROLIDIN-1-YL)PYRIMIDINES BY REACTIONS OF N-(4,4-DIETHOXYBUTYL)PYRIMIDIN-2-AMINE WITH (HETERO)AROMATIC C-NUCLEOPHILES

Андрей В. Смолобочкин, Танзиля С. Ризбаева, Альмир С. Газизов, Юлия К. Воронина, Елена А. Чугунова, Нургали И. Акылбеков, Нурбол О. Аппазов, Александр Р. Бурилов, Михаил А. Пудовик
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Abstract


A method was developed for the synthesis of 2-(pyrrolidin-1-yl)pyrimidines and 2-[(4,4-diarylbutyl)amino]pyrimidines by reactions of (hetero)aromatic C-nucleophiles with N-(4,4-diethoxybutyl)pyrimidin-2-amine in the presence of trifluoroacetic acid. The structures of the obtained products were confirmed by methods of IR spectroscopy, 1Н, 13С NMR spectroscopy, and X-ray structural analysis.


Keywords


N-(4,4-diethoxybutyl)pyrimidin-2-amine; (hetero)aromatic nucleophile; 2-(pyrrolidin-1-yl)pyrimidine; trifluoroacetic acid

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