SYNTHESIS OF PYRAZOLO[1,5-<i>a</i>]PYRAZIN-4-YLACETONITRILES AND THEIR ANNULATION WITH PYRIDINE RING

Authors

  • Назар М. Цизорик Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine
  • Евгений В. Гринишин National University of Kyiv-Mohyla Academy, 2 Hryhoriya Skovorody St., Kyiv 04655, Ukraine
  • Анна Р. Мусийчук Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine
  • Андрей В. Больбут Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine
  • Михаил В. Вовк Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine

DOI:

https://doi.org/10.1007/5236

Keywords:

4-chloropyrazolo[1, 5-a]pyrazines, pyrazolo[1, 5-a]pyrazin-4-ylacetonitriles, 5-a]pyrido[2, 1-c]pyrazines, annulation.

Abstract

A reaction of 4-chloropyrazolo[1,5-a]pyrazines with tert-butyl cyanoacetate proceeded via the formation of tert-butyl cyano(pyrazolo[1,5-a]pyrazin-4(5H)-ylidene)ethanoates as intermediates and led to pyrazolo[1,5-a]pyrazin-4-ylacetonitriles, which were used to obtain derivatives of a new pyrazolo[1,5-a]pyrido[2,1-c]pyrazine system.

Author Biographies

Назар М. Цизорик, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine

мнс в Институте органической химии НАН Украины

Евгений В. Гринишин, National University of Kyiv-Mohyla Academy, 2 Hryhoriya Skovorody St., Kyiv 04655, Ukraine

Аспирант в “Киево-Могилянской академии"

Анна Р. Мусийчук, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine

Инженер в Институте органической химии НАН Украины

Андрей В. Больбут, Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine

снс в Институте органической химии НАН Украины

Михаил В. Вовк, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine

дхн, проф. в Институте органической химии НАН Украины

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Published

2019-09-17

Issue

Vol. 55 No. 9 (2019)

Section

Short Communications