1-(TRIFLUOROMETHYL)-3,4-DIHYDROPYRROLO-[1,2-a]PYRAZINES: SYNTHESIS AND REACTIONS WITH O- AND N-NUCLEOPHILES

Abstract

The method of synthesis has been developed and reactions of 1-(trifluoromethyl)-3,4-dihydro-pyrrolo[1,2-a]pyrazines with O- and N-nucleophiles have been studied. It was found that reactions of nucleophiles with 1-(trifluoro-methyl)pyrrolo[1,2-a]pyrazines transforms the trifluoromethyl group to amide and amidine groups together with aromatization of the pyrrolo[1,2-a]pyrazine system as a result of the formal elimination of a molecule of hydrogen fluoride.

How to Cite
Terenin, V. I.; Galkin, M. V.; Kabanova, E. V.;  Ivanov, A. S. Chem. Heterocycl. Compd. 2011, 46, 1271. [Khim. Geterotsikl. Soedin. 2010, 1569.]

For this article in the English edition see DOI 10.1007/s10593-011-0663-x