Open Access Open Access  Restricted Access Subscription Access

A CONVENIENT METHOD FOR EFFICIENT SYNTHESIS OF ISOXAZOLE-CONTAINING THIADIAZEPINE DERIVATIVES

Александр В. Павлюк, Юрий В. Безуглый, Владимир В. Суховеев, Владимир И. Кашковский
Cover Image

Abstract


An effective strategy has been developed for the preparation of isoxazole-containing thiadiazepine derivatives via the reaction of 1,3-diallyl sulfamide with the corresponding 3-aryl-5-bromomethylisoxazoles using ring-closing metathesis as the key synthetic step. This route grants access to such thiadiazepine derivatives which cannot be synthesized by other methods.

Keywords


diallyl derivatives; isoxazole; ruthenium; sulfamides; thiadiazepine; metathesis reaction.

Full Text: PDF (Russian) Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv