

A CONVENIENT METHOD FOR EFFICIENT SYNTHESIS OF ISOXAZOLE-CONTAINING THIADIAZEPINE DERIVATIVES

Abstract
An effective strategy has been developed for the preparation of isoxazole-containing thiadiazepine derivatives via the reaction of 1,3-diallyl sulfamide with the corresponding 3-aryl-5-bromomethylisoxazoles using ring-closing metathesis as the key synthetic step. This route grants access to such thiadiazepine derivatives which cannot be synthesized by other methods.
Keywords
diallyl derivatives; isoxazole; ruthenium; sulfamides; thiadiazepine; metathesis reaction.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv