A CONVENIENT METHOD FOR EFFICIENT SYNTHESIS OF ISOXAZOLE-CONTAINING THIADIAZEPINE DERIVATIVES

Abstract

An effective strategy has been developed for the preparation of isoxazole-containing thiadiazepine derivatives via the reaction of 1,3-diallyl sulfamide with the corresponding 3-aryl-5-bromomethylisoxazoles using ring-closing metathesis as the key synthetic step. This route grants access to such thiadiazepine derivatives which cannot be synthesized by other methods.