Open Access Open Access  Restricted Access Subscription Access

INVESTIGATION OF THE MULTICOMPONENT REACTION OF 5-HYDROXY-2-METHYL-4H-PYRAN-4-ONE WITH CARBONYL COMPOUNDS AND MELDRUM'S ACID

Andrey N. Komogortsev, Boris V. Lichitsky, Alexander D. Tretyakov, Arkady A. Dudinov, Michail M. Krayushkin
Cover Image

Abstract


Herein, we report the studies of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid. General methods for the synthesis of 6-methyl-3,4-dihydropyrano[3,2-b]pyran-2,8-diones, 3-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)propanoic acid amides and esters, as well as 7-oxo-7H-furo[3,2-b]pyran-3-ylacetic acids were elaborated. An efficient synthesis of spiro-condensed dihydropyranones containing 5-hydroxy-2-methyl-4H-pyran-4-one fragment was developed.

Keywords


arylglyoxals; 5-hydroxy-2-methyl-4H-pyran-4-one; Meldrum's acid; multicomponent reactions; spiro compounds.

Full Text: PDF Supplementary File(s): supplementary info (3MB)


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv