SIMPLE ONE-POT SYNTHESIS OF 5-(CHLOROMETHYL)ISOXAZOLES FROM ALDOXIMES AND 2,3-DICHLORO-1-PROPENE

Authors

  • Евгений В. Кондрашов A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky St., Irkutsk 664033, Russia
  • Нина С. Шатохина A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky St., Irkutsk 664033, Russia

DOI:

https://doi.org/10.1007/5291

Keywords:

2, 3-dichloro-1-propene, isoxazoles, nitrile oxides, oximes, aromatization, 1, 3-dipolar cycloaddition, one-pot synthesis.

Abstract

A one-pot synthesis of 3-substituted 5-chloromethylisoxazoles from available starting aldoximes and 2,3-dichloro-1-propene, serving both as a solvent and reagent, is proposed. Excess 2,3-dichloro-1-propene is recovered after the reaction. The synthesis is effective for oximes of both aromatic and aliphatic aldehydes.

Author Biographies

Евгений В. Кондрашов, A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky St., Irkutsk 664033, Russia

с.н.с. лаборатории галогенорганических соединений, Иркутский институт химии

Нина С. Шатохина, A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky St., Irkutsk 664033, Russia

аспирант в лаборатории галогенорганических соединений, Иркутский институт химии

Published

2019-12-18

Issue

Section

Original Papers