

SIMPLE ONE-POT SYNTHESIS OF 5-(CHLOROMETHYL)ISOXAZOLES FROM ALDOXIMES AND 2,3-DICHLORO-1-PROPENE

Abstract
A one-pot synthesis of 3-substituted 5-chloromethylisoxazoles from available starting aldoximes and 2,3-dichloro-1-propene, serving both as a solvent and reagent, is proposed. Excess 2,3-dichloro-1-propene is recovered after the reaction. The synthesis is effective for oximes of both aromatic and aliphatic aldehydes.
Keywords
2,3-dichloro-1-propene; isoxazoles; nitrile oxides; oximes; aromatization; 1,3-dipolar cycloaddition; one-pot synthesis.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv