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SIMPLE ONE-POT SYNTHESIS OF 5-(CHLOROMETHYL)ISOXAZOLES FROM ALDOXIMES AND 2,3-DICHLORO-1-PROPENE

Евгений В. Кондрашов, Нина С. Шатохина
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Abstract


A one-pot synthesis of 3-substituted 5-chloromethylisoxazoles from available starting aldoximes and 2,3-dichloro-1-propene, serving both as a solvent and reagent, is proposed. Excess 2,3-dichloro-1-propene is recovered after the reaction. The synthesis is effective for oximes of both aromatic and aliphatic aldehydes.

Keywords


2,3-dichloro-1-propene; isoxazoles; nitrile oxides; oximes; aromatization; 1,3-dipolar cycloaddition; one-pot synthesis.

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