Open Access Open Access  Restricted Access Subscription Access

SYNTHESIS OF NOVEL 2'-ARYL-4'-HYDROXY-4',5,5',6-TETRAHYDRO-2'H,8H-SPIRO[INDOLIZINE-7,3'-THIOPHEN]-8-ONE DERIVATIVES via SULFA-MICHAEL/ALDOL CASCADE REACTIONS

Yulin Huang, Guihua Tang, Demin Ren, Ju-Lan Zeng, Xiaofang Li
Cover Image

Abstract


The sulfa-Michael/aldol cascade reaction of (E)-7-arylidene-6,7-dihydroindolizin-8(5H)-ones and 1,4-dithiane-2,5-diol afforded novel
2'-aryl-4'-hydroxy-4',5,5',6-tetrahydro-2'H,8H-spiro[indolizine-7,3'-thiophen]-8-ones in low to moderate yields. The structures of all products were characterized thoroughly by NMR, IR, HRMS, together with X-ray crystallographic analysis.


Keywords


1,4-dithiane-2,5-diol; 6,7-dihydroindolizin-8(5H)-one; sulfa-Michael/aldol cascade reaction; spiro heterocycle

Full Text: PDF Supplementary File(s): supplementary info (843KB)


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv