

A FOUR-COMPONENT BIGINELLI REACTION: NEW OPPORTUNITIES FOR THE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES

Abstract
Methyl 5-aroyl-6-aryl-4-methoxy-2-oxo(thioxo)hexahydropyrimidine-4-carboxylates were synthesized by four-component Biginelli reaction of methyl aroylpyruvate, aromatic aldehyde, urea (thiourea), and MeOH in the presence of NaHSO4. The products were obtained in moderate to high yields.
Keywords
aromatic aldehyde; hexahydropyrimidine; methyl aroylpyruvate; thiourea; urea; Biginelli reaction; X-ray structural analysis
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv