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A FOUR-COMPONENT BIGINELLI REACTION: NEW OPPORTUNITIES FOR THE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES

Vladimir L. Gein, Tatiana M. Zamaraeva, Ekaterina V. Gorgopina, Maksim V. Dmitriev
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Abstract


Methyl 5-aroyl-6-aryl-4-methoxy-2-oxo(thioxo)hexahydropyrimidine-4-carboxylates were synthesized by four-component Biginelli reaction of methyl aroylpyruvate, aromatic aldehyde, urea (thiourea), and MeOH in the presence of NaHSO4. The products were obtained in moderate to high yields.


Keywords


aromatic aldehyde; hexahydropyrimidine; methyl aroylpyruvate; thiourea; urea; Biginelli reaction; X-ray structural analysis

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