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SYNTHESIS OF 6b,11b-DIHYDROXY-12-METHYLPHENYL-11b,12-DIHYDROBENZO[g]INDENO[1,2-b]INDOLE-5,6,7(6bH)-TRIONES AND 2-(3-HYDROXY-4,9-DIOXO-4,9-DIHYDRO-1H-BENZO[f]INDOL-2-YL)BENZAMIDES, THEIR STRUCTURE AND ANTIPROLIFERATIVE ACTIVITY

Леонид М. Горностаев, Ольа И. Фоминых, Татьяна А. Руковец, Татьяна И. Лаврикова, Юлия Г. Халявина, Александр А. Штиль, Алексей В. Шунаев, Сергей Ф. Дунаев, Елена В. Мурашова, Владимир В. Чернышев
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Abstract


Methods of synthesis of 6b,11b-dihydroxy-12-methylphenyl-11b,12-dihydrobenzo[g]indeno[1,2-b]indole-5,6,7(6bH)-triones and 2(3hydroxy-4,9-dioxo-4,9-dihydro-1H-benzo[f]indol-2-yl)benzamides are proposed. It was found that 6b,11b-dihydroxy-12-(3-methylphenyl)-11b,12-dihydrobenzo[g]indeno[1,2-b]indole-5,6,7(6bH)-trione exists as two stereoisomers. The antiproliferative activity of 6b,11b-dihydroxy-12-methylphenyl-11b,12-dihydrobenzo[g]indeno[1,2-b]indole-5,6,7(6bH)-triones and 2-(3-hydroxy-4,9-dioxo-4,9dihydro-1H-benzo[f]indol-2-yl)benzamides against human tumor and nontumor cells along with the features of their structures that are important for the manifestation of this activity has been established.

 


Keywords


2-alkylamino-1,4-naphthoquinones; 4-arylamino-1,2-naphthoquinones; 2-(3-hydroxy-4,9-dioxo-4,9-dihydro-1H-benzo[f]indol-2-yl)benzamides; 2,2-dihydroxy-1,3-indanedione; 6b,11b-dihydroxy-12-methylphenyl-11b,12-dihydrobenzo[g]indeno[1,2-b]-indole-5,6,7(6bH)triones.

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