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SODIUM HYPOCHLORITE-MEDIATED SYNTHESIS OF 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES FROM HYDRAZIDES AND ALDEHYDES

Karuna Raman Paidi, Murali Krishna Kolli, Eeda Koti Reddy, Venkata Ramana Pedakotla
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Abstract


A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.


Keywords


N-acylhydrazone; aldehyde; hydrazide; oxadiazole; sodium hypochlorite; oxidative cyclization.

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