THE PRODUCTS OF SUZUKI REACTION OF ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-<i>d</i>]PYRIMIDINE-6-CARBOXYLATE WITH POTASSIUM ALLYLTRIFLUOROBORATE AND TRANSFORMATIONS THEREOF

Authors

  • Konstantin Yu. Krolenko Selvita S. A., Park Life Science, Discovery Chemistry Department, 14 Bobrzynskiego St., Krakow 30-348
  • Sergiy V. Vlasov National University of Pharmacy, 53 Pushkinska St., Kharkiv 61002

DOI:

https://doi.org/10.1007/5334

Keywords:

hexa-1, 5-dien-3-yl derivatives, potassium allyltrifluoroborate, thieno[2, 3-d]pyrimidine, Cope rearrangement, Suzuki reaction

Abstract

5-Methylthieno[2,3-d]pyrimidine-6-carboxylates substituted with prop-1-en-1-yl and hexa-1,5-dien-3-yl fragments in the C-4 position of the heterocycle were obtained in Suzuki coupling reaction of potassium allyltrifluoroborate and ethyl 4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate. Further transformations of the products allowed confirming the structure and molecular geometry of the obtained compounds.

Author Biographies

Konstantin Yu. Krolenko, Selvita S. A., Park Life Science, Discovery Chemistry Department, 14 Bobrzynskiego St., Krakow 30-348

I work on a position of Scientist II in the department of discovery chemistry in Selvita S. A., Park Life Science, 14 Bobrzynskiego str. 30-348 Krakow, Poland

Sergiy V. Vlasov, National University of Pharmacy, 53 Pushkinska St., Kharkiv 61002

Docent of organic chemistry department

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Published

2019-12-18

Issue

Vol. 55 No. 12 (2019)

Section

Original Papers