FACILE SYNTHESIS OF ISONIAZID DERIVATIVES – 1-[2-(3-ARYL(HETARYL)-1-PHENYL-1<i>H</i>-PYRAZOL-4-YL)-5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOL-3(2<i>H</i>)-YL]ETHANONES

Authors

  • Faryal Chaudhry Department of Chemistry, Kinnaird College for Women Lahore, 93-Jail Road, Lahore-54000, Pakistan; Institute of the Chemistry, Quaid-e-Azam Campus, University of the Punjab, Lahore-54590, Pakistan
  • Munawar Ali Munawar Institute of the Chemistry, Quaid-e-Azam Campus, University of the Punjab, Lahore-54590, Pakistan
  • Misbahul Ain Khan Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore-54590, Pakistan Department of Chemistry, The Islamia University of Bahawalpur Pakistan, Bahawalpur-63100, Pakistan
  • Misbahul Ain Khan Institute of the Chemistry, Quaid-e-Azam Campus, University of the Punjab, Lahore-54590, Pakistan; Department of Chemistry, the Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan

DOI:

https://doi.org/10.1007/5357

Keywords:

acylhydrazones, coumarins, hetaryloxadiazoles, isoniazid, ultrasonication.

Abstract

A facile and efficient ultrasound-aided approach has afforded cyclization of isoniazid hydrazones into 2,5-bishetaryloxadiazolines at ambient temperature. Acetic anhydride helped in intramolecular oxidative cyclization along with N-acylation of oxadiazoline. The synthesized 1-[2-(1-phenyl-1H-pyrazol-4-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethanones were isolated in good yields, spectral data supported the proposed structures.

Author Biographies

Faryal Chaudhry, Department of Chemistry, Kinnaird College for Women Lahore, 93-Jail Road, Lahore-54000, Pakistan; Institute of the Chemistry, Quaid-e-Azam Campus, University of the Punjab, Lahore-54590, Pakistan

Assistant Professor, Department of Chemistry, Kinnaird College for Women Lahore, 93-Jail Road, Lahore-54000, Pakistan

Munawar Ali Munawar, Institute of the Chemistry, Quaid-e-Azam Campus, University of the Punjab, Lahore-54590, Pakistan

Professor, Institute of Chemistry, University of the Punjab, Lahore

Misbahul Ain Khan, Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore-54590, Pakistan Department of Chemistry, The Islamia University of Bahawalpur Pakistan, Bahawalpur-63100, Pakistan

Professor, Institute of Chemistry, University of the Punjab, Lahore

Misbahul Ain Khan, Institute of the Chemistry, Quaid-e-Azam Campus, University of the Punjab, Lahore-54590, Pakistan; Department of Chemistry, the Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan

Professor, Institute of Chemistry, University of the Punjab, Lahore

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Published

2020-05-28

Issue

Vol. 56 No. 5 (2020)

Section

Short Communications