A CONVENIENT METHOD OF SYNTHESIS OF 8-ACYL-2,3,6,7-TETRAHYDRO-5 Н -[1,3]THIAZOLO[3,2- c ]PYRIMIDIN-5-ONES

Мария Б. Литвинчук; Антон В. Бентя; Наталия Ю. Сливка; Эдуард Б. Русанов; Михаил В. Вовк

doi:10.1007/5383

A CONVENIENT METHOD OF SYNTHESIS OF 8-ACYL-2,3,6,7-TETRAHYDRO-5Н-[1,3]THIAZOLO[3,2-c]PYRIMIDIN-5-ONES

Мария Б. Литвинчук, Антон В. Бентя, Наталия Ю. Сливка, Эдуард Б. Русанов, Михаил В. Вовк

Abstract

5-Substituted (1,3-thiazolidin-2-ylidene)ketones react regioselectively with 1-chlorobenzyl isocyanates under mild conditions to form diastereomeric 8-acyl-2,3,6,7-tetrahydro-5H-[1,3]thiazolo[3,2-c]pyrimidin-5-ones, the relative configuration of the chiral centers of which was determined by X-ray structural analysis.

Keywords

1-chlorobenzyl isocyanates; (1,3-thiazolidin-2-ylidene)ketones; [1,3]thiazolo[3,2-c]pyrimidines; cyclocondensation.

Full Text: PDF (Russian) Open Access

Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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