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MAGNETIC SILICA NANOPARTICLE-SUPPORTED COPPER COMPLEX AS AN EFFICIENT CATALYST FOR THE SYNTHESIS OF NOVEL TRIAZOLOPYRAZINYLACETAMIDES WITH IMPROVED ANTIBACTERIAL ACTIVITY

Mohammad Sadegh Asgari, Saghi Sepehri, Saeed Bahadorikhalili, Parviz Rashidi Ranjbar, Rahmatollah Rahimi, Ahmad Gholami, Aboozar Kazemi, Mehdi Khoshneviszadeh, Bagher Larijani, Mohammad Mahdavi
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Abstract


A novel superparamagnetic iron oxide modified with copper via 2-aminobenzamide is synthesized by the modification of Fe3O4@SiO2
with amine, followed by the reaction with isatoic anhydride. The catalyst is fully characterized by various methods. The catalytic activity of the catalyst is evaluated in the synthesis of a series of novel N-alkyl-2-aryl-2-(6-oxo-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)acetamide analogs. Antibacterial activity of the synthesized compounds is evaluated. The catalyst is recoverable and shows excellent reusability in 10 sequential runs.


Keywords


nanoparticle-supported copper catalyst; triazole; antibacterial agents; click reaction; structure–activity relationship.

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv