

SYNTHESIS AND SOME CHEMICAL PROPERTIES OF 2-CYANO-4-PYRONE

Abstract
2-Cyano-4-pyrone obtained from comanic acid ethyl ester reacts with amines and hydrazines with the opening of the pyrone ring and substitution of the cyano group to form carbamoylated aminoenones (yields 62–87%) and pyrazolylacetic acid hydrazides. The reactions of 2-cyano-4-pyrone with hydroxylamine or sodium azide involve exclusively the cyano group, which makes it possible to obtain 2-heteroaryl-4-pyrones and 2-heteroaryl-4-hydroxypyridines.
Authors: Dmitrii L. Obydennov*, Aleksandra I. Suslova, Vyacheslav Ya. Sosnovskikh
Keywords
carbamoylated enaminones; 2-cyano-4-pyrones; 2-heteroaryl-4-hydroxypyridines; 2-heteroaryl-4-pyrones; 4-oxo-1,4-dihydropyridine-3-carboxamides; pyrazoles
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv