

TETRAKIS(HYDROXYMETHYL)GLYCOLURIL IN N-METHYLENATION REACTIONS WITH ARYLAMINES

Abstract
This work shows for the first time the use of tetrakis(hydroxymethyl)glycoluril in the melt N-methylenation reactions of arylamines, based on the ability of tetrakis(hydroxymethyl)glycoluril to eliminate a formaldehyde molecule. It was shown by HPLC that tetrakis-(hydroxymethyl)glycoluril under the studied conditions is subject to dehydroxymethylation processes.
Keywords
aminals; arylamines; formaldehyde; tetrakis(hydroxymethyl)glycoluryl; dehydroxymethylation; HPLC.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv