

A PERSPECTIVE ON ENVIRONMENTALLY BENIGN PROTOCOLS OF THIAZOLE SYNTHESIS

Abstract
Thiazole has widespread importance in materials and medicines. Several reviews are reported which cover essential properties of thiazoles such as pharmacological activities, structure-activity relationship studies, and various synthetic routes. However, synthesis based on a greener approaches, particularly metal-free reactions, usage of mild, nontoxic, recyclable catalysts, eco-sustainable protocols, efficient solvents have not been exclusively reviewed. Current review emphasizes green synthetic approaches for substituted thiazoles that have been performed within the last decade.
Keywords
thiazole; biodegradable chemicals; catalyst-free synthesis; environment-friendly synthesis; green synthesis; solvent-free synthesis.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv