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SYNTHESIS AND EVALUATION OF BIOLOGICAL ACTIVITY OF HOMODRIMANE SESQUITERPENOIDS BEARING 1,3,4-OXADIAZOLE OR 1,3,4-THIADIAZOLE UNITS

Lidia Lungu, Alexandru Ciocarlan, Crina Smigon, Ilker Ozer, Sergiu Shova, Iacob Gutu, Nicoleta Vornicu, Ionel Mangalagiu, Michele D'Ambrosio, Aculina Aricu
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Abstract


Synthesis of novel (+)-sclareolide-based homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units has been reported. These terpeno-heterocyclic compounds demonstrate promising antifungal and antibacterial activities toward fungal species Aspergillus niger, Fusarium solani, Penicillium chrysogenum, Penicillium frequentans, and Alternaria alternata and bacteria strains Pseudomonas aeruginosa and Bacillus sp. with minimum inhibitory concentration at µg/ml level.


Keywords


homodrimane sesquiterpenoid; oxadiazole; thiadiazole; antibacterial activity; antifungal activity.

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