The reaction of 3-[(alkylsulfanyl)methyl]pentane-2,4-diones with nicotinic hydrazide in ethanol as solvent produces 4-[(alkylsulfanyl)methyl]-substituted 1-(pyridin-3-yl)carbonyl-1H-pyrazoles, whereas 1-acyl-1H-pyrazoles are formed in acetic, propanoic, or pentanoic acid solution. The reaction in methanol in the presence of ZnCl2 is accompanied by elimination of nicotinic acid and the formation of (alkylsulfanyl)methyl-substituted 1H-pyrazoles.
Author Biographies
Лариса А. Баева, Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences,
69 Oktyabrya Ave., Ufa 450054, Russia
лаборатория химической кинетики, ст.н.с., доцент
Радик М. Нугуманов, Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences,
69 Oktyabrya Ave., Ufa 450054, Russia
лаборатория химической кинетики, ст. инженер
Раил Р. Гатауллин, Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences,
69 Oktyabrya Ave., Ufa 450054, Russia
лаборатория фармакофорных циклических систем, в.н.с.
Ахнэф А. Фатыхов, Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences,
69 Oktyabrya Ave., Ufa 450054, Russia
лаборатория физико-химических методов анализа, с.н.с.
